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  • Writer's pictureBilly

The Evolution of 5-MeO-DiPT: A Historical Perspective on Psychedelic Exploration

Updated: Jun 7, 2023


This psychedelic art-style image portrays a fox, a symbol of adaptability and intelligence, piloting a UFO through a galaxy of vibrant colors. The image captures the essence of a 5-MeO-DiPT journey – an explorative voyage into the unknown realms of consciousness, guided by the transformative power of the psychedelic experience.

The Genesis of 5-MeO-DiPT: Alexander Shulgin's Revolutionary Contribution


The legacy of 5-MeO-DiPT, a compound intriguing psychonauts and researchers alike, traces back to a single extraordinary man: Alexander Shulgin, a pioneer of psychedelic research. Often referred to as the 'Godfather of Psychedelics', Shulgin's work reshaped our understanding of these substances and opened new vistas in the exploration of human consciousness.


Born in 1925, Shulgin displayed a keen interest in chemistry from an early age. His career spanned across various sectors including serving as a chemical consultant, teaching public health at the University of California, Berkeley, and working as a senior research chemist at Dow Chemicals. However, it was a serendipitous encounter with mescaline in 1960 that set the course for Shulgin's life's work.

Impacted deeply by the mescaline experience, Shulgin was drawn to the study of psychedelic substances, fascinated by their capacity to profoundly alter human perception and consciousness. This fascination evolved into a lifelong pursuit of understanding and creating novel psychoactive substances.


Shulgin approached his work with a sense of scientific rigor and personal exploration. Not content with merely theorizing the effects of these substances, he took it upon himself to personally test them. He would often start with very low doses, incrementally increasing the amount to understand the full spectrum of effects. His firsthand accounts served as invaluable primary resources, providing detailed insights into the physical and psychological effects of these compounds.

In 1985, Shulgin introduced the world to 5-MeO-DiPT, a synthetic tryptamine with unique sensory and emotional effects. The meticulous chemist carefully documented his experiences with this novel substance in his ground-breaking book "TiHKAL: Tryptamines I Have Known and Loved". This publication not only details the synthesis of 5-MeO-DiPT and Shulgin's personal experiences but also includes various trip reports from his research group.


Shulgin's description of 5-MeO-DiPT in "TiHKAL" portrays it as a substance with a unique personality. According to him, it provided a sensual and emotionally open experience with distinctive auditory distortions, distinguishing it from other psychedelic tryptamines. The effects, which could last between 4-8 hours, usually started 20-40 minutes after ingestion.


The creation of 5-MeO-DiPT marked yet another landmark in Shulgin's illustrious career. His vast contribution to the field of psychedelic research, including the synthesis of over 200 psychedelic compounds, continues to inspire and inform researchers, explorers of consciousness, and psychonauts. The legacy of 5-MeO-DiPT, as with many other substances from Shulgin's extensive repertoire, serves as a testament to his curiosity, dedication, and pioneering spirit in the realm of psychoactive substances.

The Rise of 'Foxy' and Its Influence on Popular Culture

In the early 2000s, 5-MeO-DiPT saw a surge in recreational use, particularly within the rave and party scenes. Its relatively short duration of action, combined with its unique mix of psychedelic and entactogenic effects, made it popular among those seeking an alternative to more traditional substances like LSD or MDMA. Users reported a range of effects, from enhanced tactile sensations and auditory distortions to feelings of emotional openness and empathy. The popularity of 'Foxy' grew, but so did its reputation for unpredictable effects, leading to an increase in hospitalizations and adverse events.

By the mid-2000s, 5-MeO-DiPT was classified as a Schedule I substance in the United States, making its use, possession, and distribution illegal. The legal restrictions led to a decline in its use, but the interest in 5-MeO-DiPT remained, albeit underground.

A Shift in Perception: 5-MeO-DiPT as a Tool for Therapy and Personal Growth

In recent years, as society has begun to reassess the therapeutic potential of psychedelics, 5-MeO-DiPT has also seen a resurgence of interest. Current research suggests it may hold potential in the treatment of various mental health conditions, including depression and anxiety.

The use of 5-MeO-DiPT has evolved from recreational to therapeutic and spiritual contexts. An increasing number of individuals are turning to 5-MeO-DiPT as a tool for personal growth and spiritual exploration, often in the context of guided, ceremonial settings. These structured, supportive environments allow for a safer exploration of the self and consciousness, guided by experienced facilitators.

The Future of 5-MeO-DiPT: Research, Potential, and Acceptance

The future of 5-MeO-DiPT looks promising. With a growing acceptance of psychedelics' therapeutic potential, research into substances like 5-MeO-DiPT is likely to increase. These studies, both clinical and anecdotal, will continue to deepen our understanding of this unique compound and its potential for healing and transformation.

5-MeO-DiPT's journey, from its synthesis in a laboratory to its current standing in the realm of psychedelic substances, is a testament to the evolving understanding of these powerful tools. As we continue to explore its potential, we should remember the importance of safety, respect, and intention in our approach.

At TripSafely, we're committed to fostering a safe and supportive environment for individuals seeking to embark on their own psychedelic journeys. If you're interested in learning more about 5-MeO-DiPT or our upcoming group medicine events, we invite you to sign up for our weekly newsletter at www.tripsafely.ca. Your journey to self-discovery could start with a single step. Reach out today!

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